Owner complaints, recalls, fuel economy and safety ratings from public NHTSA and EPA data, updated Oct 18, 2026.
Fuel economy
23–26 mpgcombined; city 21–23, highway 26–30; every version of this model year
Five years of fuel
$15,480–$17,500U.S. average; Ohio $14,580–$16,490 at local prices; every version of this model year; fuel only, not other costs of owning it; 15,000 miles a year, at EIA fuel prices for the week of Oct 12, 2026
NHTSA overall safety rating
Not ratedNHTSA has no overall rating for this year
NHTSA's VIN data lists these trims for the 2021 CLS-Class. A trim's engine and numbers are shown as its own only where EPA names versions after the trim and no other version could be it; "seen with" means a source shows that engine on the trim, not that it was the only one. Recalls and complaints cover the whole model year: whether a recall applies to a car depends on its VIN, on NHTSA's recall lookup.
Owners have filed 2 complaints with NHTSA about the 2021 CLS-Class. These are unverified owner reports, counted by the part of the car they name; one complaint can name several parts. Counts aren't adjusted for how many were sold, so they don't show how reliable a car is.
Complaints by part of the car
Part
Complaints
Crashes
Fires
Injuries
Electrical system
1
0
0
0
Wheels
1
0
0
0
What the columns count
Complaints: complaints that name that part. One complaint can name several parts, so the rows overlap and don't add up to the total.
Crashes and Fires: complaints that report one. Two owners can file about the same event, and NHTSA doesn't link them, so these count reports, not events.
Injuries: the number of people the complaints say were injured.
None of these columns shows that a part caused a crash, fire or injury: they're what owners reported, unverified.
Complaints by model year
Newer years have had less time to collect complaints, and counts aren't adjusted for sales, so a shorter bar doesn't mean a more reliable year.
NHTSA lists 11 recall campaigns for the 2021 CLS-Class over its history, 1 replaced by a later one. A replaced campaign is listed at the end as history, not as a separate repair. Campaigns are matched by model and year, so each one may apply to a given car, and its repair may already be done: check a VIN on NHTSA's recall lookup for the open recalls on that exact car.
Electrical system: wiring
NHTSA campaign 24V445000 · reported Jun 14, 2024 · 22,422 vehicles potentially affected across the whole campaign
Remedy: Dealers will replace the two-part wiring harness and connector, free of charge. Interim letters, notifying owners of the safety risk, were mailed August 9, 2024. A second notice will be sent once the final remedy is available. Owners may contact MBUSA customer service at 1-877-496-3691. MBUSA's number for this recall is 2024100002/3. This recall supersedes recall 22V-533. Vehicles repaired under the prior recall will still need to have the new remedy performed.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2021 CLS 53 4MATIC, 2019-2023 E 53 4MATIC Cabriolet, E 53 4MATIC Coupe, E 53 4MATIC Sedan, 2021-2024 GT 43 4MATIC, and 2019-2025 GT 53 4MATIC vehicles. The transmission wiring harness connection might not have been correctly wired during a prior recall repair, and during production. which can expose the electrical connector to corrosion, and result in an electrical short-circuit.
Risk: An electrical short circuit can increase the risk of a fire.
NHTSA campaign 24V100000 · reported Feb 9, 2024 · 12,191 vehicles potentially affected across the whole campaign
Remedy: Dealers will inspect the 48-volt ground cable connection and repair it as necessary, free of charge. Owner notification letters were mailed March 22, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2024MMNNNN.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 CLS450, E450, E450 All-Terrain, AMG E53, AMG GT43, AMG GT53, and 2021 AMG CLS53 vehicles. The 48-volt ground cable connection located in the engine compartment may not be tightened properly and may result in the ground cable overheating.
Risk: An overheated ground cable increases the risk of a fire.
NHTSA campaign 22V733000 · reported Sep 30, 2022 · 19,968 vehicles potentially affected across the whole campaign
Remedy: Dealers will secure the 12V battery, free of charge. Owner notification letters were mailed January 20, 2023. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022100009.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2022 CLS450 Coupe and AMG E53, 2019-2021 AMG CLS53 Coupe, and 2021-2022 E450 vehicles. The 12-Volt battery in the trunk may not be properly secured, which, in the event of a crash, can cause electrical connection failure, disabling various safety features including, emergency call (eCall) system, electric seat adjustment, hazard warning lights, and automatic door locks.
Risk: The inability to operate safety features (eCall system, hazard lights, electric seats, or automatic door locks) can increase the risk of injury during a crash.
Communication: auto crash notification; Electrical system: software
NHTSA campaign 22V365000 · reported May 20, 2022 · 242,722 vehicles potentially affected across the whole campaign
Remedy: The communication module software will be updated through an Over-the-Air (OTA) update or by a dealer, free of charge. Owner notification letters were mailed July 8, 2022. Owner notification letters will be mailed in phases, on July 8, 2022, May 17, 2024, July 29, 2024, and September 27, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's numbers are for this recall is 2022060005 and 2023110006.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2017-2022 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, AMG GT-Class, C-Class, E-Class, S-Class, SL-Class, GLC-Class, CLS-Class, GLB-Class, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. An error in the communication module's SIM card software can cause a mobile network connection failure, disabling the emergency call (eCall) system.
Risk: A disabled eCall system would prevent a vehicle occupant from contacting the emergency services call center in an emergency, potentially delaying emergency responders and increasing the risk of injury.
NHTSA campaign 22V189000 · reported Mar 25, 2022 · 8,396 vehicles potentially affected across the whole campaign
Remedy: Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040010.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel. Due to a software error in the hand detection control unit, the hands-off detection might not detect when the driver's hands are away from the steering wheel when using the Active Distance Assist DISTRONIC system.
Risk: Deactivated hands-off detection will prevent DISTRONIC system features from functioning, including warnings to grab the steering wheel and calling first responders as part of the Active Emergency Stop Assist, which can increase the risk of a crash or injury.
NHTSA campaign 21V527000 · reported Jul 12, 2021 · 542 vehicles potentially affected across the whole campaign
Remedy: Dealers will inspect and replace as necessary, the side impact crash sensors, free of charge. Owner notification letters were mailed on September 3, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021070032/33.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 CLS450, AMG E53, AMG CLS53, E350, E450, AMG GT43, AMG GT53, 2020 S450, S560, G550, AMG GLC63, 2020-2021 GLC300, and AMG G63 vehicles. The side crash sensor connectors may come loose, which could delay the activation of air bags and seatbelts during a side impact crash.
Risk: Air bags and seatbelts that don't function as intended can increase the risk of injury during a crash.
NHTSA campaign 21V483000 · reported Jun 25, 2021 · 4,917 vehicles potentially affected across the whole campaign
Remedy: Dealers will inspect, and replace as necessary, the rear seat belt assemblies, free of charge. Owners notified of the voluntary recall campaign by an interim letter on August 13, 2021. A final letter was mailed on September 24, 2021. Owners may contact MBUSA customer service at 1-800-367-6372.
Mercedes-Benz, LLC (MBUSA) is recalling certain 2021 G550, AMG G63, E350, E450, AMG CLS53, AMG E53, AMG GT43, AMG GT53, AMG GT63, 2021-2022 CLS450, and AMG E63 vehicles. The rear seat belt automatic locking retractors may deactivate early, which can prevent the child restraint system from securing properly. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 208, "Occupant Crash Protection."
Risk: An unsecured child restraint system can increase the risk of injury during a crash.
Back over prevention: sensing system; Electrical system: software
NHTSA campaign 21V354000 · reported May 14, 2021 · 343,191 vehicles potentially affected across the whole campaign
Remedy: The multimedia system software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. Owner notification letters were mailed beginning June 28, 2021. Owners may contact MBUSA customer service at 1-800-367-6373. MBUSA's number for this recall is 2021050012.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2021 CLA-Class, GLE/GLS-Class, A-Class, E-Class, E-Class Coupe and Convertible, GLA/GLB-Class, GLC-Class, CLS-Class, and AMG GT-Class 4-door Coupe vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The MBUX multimedia system software may cause the display to remain black, or reboot after startup. This could result in the rearview camera image not displaying properly. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard (FMVSS) number 111, "Rear Visibility."
Risk: A backup camera that displays a blank image reduces the driver's rear view, increasing the risk of a crash or injury.
NHTSA campaign 21V230000 · reported Apr 1, 2021 · 8,634 vehicles potentially affected across the whole campaign
Remedy: MBUSA will notify owners, and dealers will replace the seat position switches, free of charge. Owner letters were mailed May 21, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021040016.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 C-Class, E-Class, E-Class Coupe and Convertible, GLC, CLS, AMG GT 4-door Coupe and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. A faulty electrical contact within the seat position switch may prevent the driver and passenger air bags and seat belt force limiters from properly activating during a crash.
Risk: Air bags and seat belts that do not perform properly in a crash can increase the risk of injury.
Communication: auto crash notification; Electrical system: software
NHTSA campaign 21V058000 · reported Feb 5, 2021 · 1,292,258 vehicles potentially affected across the whole campaign
Remedy: MBUSA will notify owners, and the communication module software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. The recall began March 12, 2021. Owners may contact MBUSA customer service at 1-877-762-8267. MBUSA's number for this recall is 2021020025.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2016 - 2021 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, GT-Class, C-Class, E-Class, S-Class, CLS-Class, SL-Class, B-Class, GLB-Class, GLC-Class, and G-Class vehicles. Please refer to the Part 573 report for specific vehicle model details. The software design of the communication module may fail to communicate the correct vehicle location for the emergency call system (eCall) in the event of a crash.
Risk: Failure of the eCall system may result in emergency responders being dispatched to the wrong location, increasing the risk of injury following a crash.
NHTSA campaign 22V533000 · reported Jul 22, 2022 · 16,977 vehicles potentially affected across the whole campaign
Replaced by campaign 24V445000, as NHTSA's record says: history, not a separate repair.
Remedy: Dealers will inspect and repair the electrical connector, as necessary. Dealers will also reroute the harness and install an additional bracket. All repairs will be performed free of charge. Owner notification letters were mailed October 14, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022080010.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 AMG GT43, 2019-2022 AMG E53, E53 Coupe, E53 Cabriolet, AMG GT53, and 2019-2021 AMG CLS53 vehicles. The transmission wiring harness may be misrouted, which can expose the electrical connector to corrosion, and result in an electrical short-circuit.
Risk: An electrical short-circuit can increase the risk of a fire.
Carmakers sent NHTSA 181 service bulletins and notices that cover the 2021 CLS-Class, the latest on Sep 26, 2026. They tell dealers how to fix known issues.
The parts they mention most: electrical system (82), power train (31), equipment (16), structure (14), steering (13).
NHTSA hasn't opened a defect investigation that covers this model year.
Maintenance
Oil
The owner's manual gives the oil and how often to change it. We show oil facts only once we've checked them against the manual, and we haven't yet for the 2021 CLS-Class.
EPA class: compact cars. EPA greenhouse gas score: 5 out of 10. Each version EPA tested:
Swipe the table sideways for more columns.
Version
Engine
Transmission
Fuel
City / hwy / comb
AMG CLS53 4matic Plus 4-Wheel Drive
3.0 L, 6 cyl
Automatic 9-spd
Premium Gasoline
21 / 26 / 23
CLS450 Rear-Wheel Drive
3.0 L, 6 cyl, turbo
Automatic 9-spd
Premium Gasoline
23 / 30 / 26
CLS450 4matic 4-Wheel Drive
3.0 L, 6 cyl, turbo
Automatic 9-spd
Premium Gasoline
22 / 29 / 25
Sources and dates
U.S. EPA fuel economy data, file of Sep 29, 2026
NHTSA owner complaints, file of Oct 18, 2026
NHTSA recalls, file of Oct 18, 2026
NHTSA manufacturer communications, file of Oct 18, 2026
NHTSA defect investigations, file of Oct 18, 2026
NHTSA 5-Star Safety Ratings, file of Aug 7, 2026
U.S. Energy Information Administration, file of Oct 12, 2026
Fuel cost: EPA mpg with fuel prices for the week of Oct 12, 2026 and electricity prices for Jul 2026. Source: U.S. Energy Information Administration (Oct 2026). Complaints are unverified reports owners filed with NHTSA. About the data