Showing the 2022 E-Class E450: EPA's E450 and E450 4matic and E450 4matic All-Terrain (3.0 L, 4WD or RWD). NHTSA's overall rating for that drive: 5 stars (4WD), 5 stars (RWD). Recalls and complaints cover the whole model year. Every version
Owner complaints, recalls, fuel economy and safety ratings from public NHTSA and EPA data, updated Oct 17, 2026.
Fuel economy
24–25 mpgcombined; city 21–23, highway 28–30; the E450
Five years of fuel
$16,100–$16,770U.S. average; Ohio $15,170–$15,800 at local prices; the E450; fuel only, not other costs of owning it; 15,000 miles a year, at EIA fuel prices for the week of Oct 12, 2026
NHTSA's VIN data lists these trims for the 2022 E-Class. A trim's engine and numbers are shown as its own only where EPA names versions after the trim and no other version could be it; "seen with" means a source shows that engine on the trim, not that it was the only one. Recalls and complaints cover the whole model year: whether a recall applies to a car depends on its VIN, on NHTSA's recall lookup.
Owners have filed 23 complaints with NHTSA about the 2022 E-Class. These are unverified owner reports, counted by the part of the car they name; one complaint can name several parts. Counts aren't adjusted for how many were sold, so they don't show how reliable a car is.
Complaints by part of the car
Part
Complaints
Crashes
Fires
Injuries
Electrical system
5
0
0
0
Forward collision avoidance
4
0
0
0
Unknown or other
4
0
0
0
Fuel system, gasoline
3
0
0
0
Steering
3
2
0
1
Wheels
3
1
0
1
Power train
2
0
0
0
Service brakes
2
0
0
0
Engine
1
0
0
0
Fuel/propulsion system
1
0
0
0
Lane departure
1
1
0
0
Structure
1
0
0
0
2 more parts
Vehicle speed control
1
0
0
0
Visibility/wiper
1
0
0
0
Complaints by model year
Newer years have had less time to collect complaints, and counts aren't adjusted for sales, so a shorter bar doesn't mean a more reliable year.
NHTSA lists 7 recall campaigns for the 2022 E-Class over its history, 1 replaced by a later one. A replaced campaign is listed at the end as history, not as a separate repair. Campaigns are matched by model and year, so each one may apply to a given car, and its repair may already be done: check a VIN on NHTSA's recall lookup for the open recalls on that exact car.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2021 CLS 53 4MATIC, 2019-2023 E 53 4MATIC Cabriolet, E 53 4MATIC Coupe, E 53 4MATIC Sedan, 2021-2024 GT 43 4MATIC, and 2019-2025 GT 53 4MATIC vehicles. The transmission wiring harness connection might not have been correctly wired during a prior recall repair, and during production. which can expose the electrical connector to corrosion, and result in an electrical short-circuit.
Risk: An electrical short circuit can increase the risk of a fire.
Remedy: Dealers will replace the two-part wiring harness and connector, free of charge. Interim letters, notifying owners of the safety risk, were mailed August 9, 2024. A second notice will be sent once the final remedy is available. Owners may contact MBUSA customer service at 1-877-496-3691. MBUSA's number for this recall is 2024100002/3. This recall supersedes recall 22V-533. Vehicles repaired under the prior recall will still need to have the new remedy performed.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 CLS450, E450, E450 All-Terrain, AMG E53, AMG GT43, AMG GT53, and 2021 AMG CLS53 vehicles. The 48-volt ground cable connection located in the engine compartment may not be tightened properly and may result in the ground cable overheating.
Risk: An overheated ground cable increases the risk of a fire.
Remedy: Dealers will inspect the 48-volt ground cable connection and repair it as necessary, free of charge. Owner notification letters were mailed March 22, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2024MMNNNN.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2024 GLE, GLS, C-Class, E-Class, S-Class, SL, GLC, CLS, AMG GT, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, causing a loss of drive power.
Risk: A loss of drive power can increase the risk of a crash.
Remedy: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 28, 2024. Owner notification letters will be mailed in phases, on February 23, 2024, April 19, 2024, June 28, 2024, August 9, 2024, October 1, 2024, and December 2, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. This recall is an expansion of NHTSA recall number 23V-445.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.
Risk: A loss of drive power can increase the risk of a crash.
Remedy: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2022 CLS450 Coupe and AMG E53, 2019-2021 AMG CLS53 Coupe, and 2021-2022 E450 vehicles. The 12-Volt battery in the trunk may not be properly secured, which, in the event of a crash, can cause electrical connection failure, disabling various safety features including, emergency call (eCall) system, electric seat adjustment, hazard warning lights, and automatic door locks.
Risk: The inability to operate safety features (eCall system, hazard lights, electric seats, or automatic door locks) can increase the risk of injury during a crash.
Remedy: Dealers will secure the 12V battery, free of charge. Owner notification letters were mailed January 20, 2023. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022100009.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel. Due to a software error in the hand detection control unit, the hands-off detection might not detect when the driver's hands are away from the steering wheel when using the Active Distance Assist DISTRONIC system.
Risk: Deactivated hands-off detection will prevent DISTRONIC system features from functioning, including warnings to grab the steering wheel and calling first responders as part of the Active Emergency Stop Assist, which can increase the risk of a crash or injury.
Remedy: Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040010.
Replaced by campaign 24V445000, as NHTSA's record says: history, not a separate repair.
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 AMG GT43, 2019-2022 AMG E53, E53 Coupe, E53 Cabriolet, AMG GT53, and 2019-2021 AMG CLS53 vehicles. The transmission wiring harness may be misrouted, which can expose the electrical connector to corrosion, and result in an electrical short-circuit.
Risk: An electrical short-circuit can increase the risk of a fire.
Remedy: Dealers will inspect and repair the electrical connector, as necessary. Dealers will also reroute the harness and install an additional bracket. All repairs will be performed free of charge. Owner notification letters were mailed October 14, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022080010.
Carmakers sent NHTSA 232 service bulletins and notices that cover the 2022 E-Class, the latest on Sep 26, 2026. They tell dealers how to fix known issues.
The parts they mention most: electrical system (92), power train (33), equipment (24), engine (20), structure (17).
NHTSA hasn't opened a defect investigation that covers this model year.
Maintenance
Oil
The owner's manual gives the oil and how often to change it. We show oil facts only once we've checked them against the manual, and we haven't yet for the 2022 E-Class.
See used 2022 Mercedes-Benz E-Classs for sale on: Autotrader · CarMax
These are searches on those sites; we don't copy or check their listings. Your ZIP is used for these links and never kept.
Specs
EPA class: subcompact cars. EPA greenhouse gas score: 5 out of 10. Each version EPA tested:
Swipe the table sideways for more columns.
Version
Engine
Transmission
Fuel
City / hwy / comb
AMG E53 4matic Plus 4-Wheel Drive
3.0 L, 6 cyl
Automatic 9-spd
Premium Gasoline
21 / 29 / 24
AMG E53 4matic Plus 4-Wheel Drive
3.0 L, 6 cyl
Automatic 9-spd
Premium Gasoline
20 / 28 / 23
AMG E53 4matic Plus 4-Wheel Drive
3.0 L, 6 cyl
Automatic 9-spd
Premium Gasoline
20 / 27 / 22
E350 Rear-Wheel Drive
2.0 L, 4 cyl, turbo
Automatic 9-spd
Premium Gasoline
23 / 31 / 26
E350 4matic All-Wheel Drive
2.0 L, 4 cyl, turbo
Automatic 9-spd
Premium Gasoline
21 / 29 / 24
E450 Rear-Wheel Drive
3.0 L, 6 cyl, turbo
Automatic 9-spd
Premium Gasoline
22 / 29 / 25
E450 4matic 4-Wheel Drive
3.0 L, 6 cyl, turbo
Automatic 9-spd
Premium Gasoline
23 / 30 / 25
E450 4matic 4-Wheel Drive
3.0 L, 6 cyl, turbo
Automatic 9-spd
Premium Gasoline
21 / 30 / 24
E450 4matic All-Terrain 4-Wheel Drive
3.0 L, 6 cyl, turbo
Automatic 9-spd
Premium Gasoline
21 / 28 / 24
Sources and dates
U.S. EPA fuel economy data, file of Sep 29, 2026
NHTSA owner complaints, file of Oct 17, 2026
NHTSA recalls, file of Oct 17, 2026
NHTSA manufacturer communications, file of Oct 17, 2026
NHTSA defect investigations, file of Oct 17, 2026
NHTSA 5-Star Safety Ratings, file of Aug 7, 2026
U.S. Energy Information Administration, file of Oct 12, 2026
Fuel cost: EPA mpg with fuel prices for the week of Oct 12, 2026 and electricity prices for Jul 2026. Source: U.S. Energy Information Administration (Oct 2026). Complaints are unverified reports owners filed with NHTSA. About the data